Early Acute Kidney Injury and Its Association With Survival in Patients With Metastatic Non‐Small‐Cell Lung Cancer Treated With Front‐Line Immunotherapy‐Based Therapies

Early Acute Kidney Injury and Its Association With Survival in Patients With Metastatic Non‐Small‐Cell Lung Cancer Treated With Front‐Line Immunotherapy‐Based Therapies

ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) have revolutionized metastatic NSCLC treatment. Acute kidney injury (AKI) is a common complication of ICI‐based therapies, alone or with chemotherapy. This study investigates the association between early AKI and 12‐month survival among patie...

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Main Authors: Mingjia Li, Po‐Lan Su, Songzhu Zhao, Grace Cheng, Nicholas Jones, Kenneth Chian, Natalie Johns, Adam Khorasanchi, Adeoluwa Adeluola, Annastasia Petouhoff, Daniel J. Spakowicz, Lai Wei, Xiaoying Wang, Christopher Coss, Mitch A. Phelps, Lingbin Meng, Yuanquan Yang, Alexa Meara, Mohamed I. Elsaid, Jinesh Gheeya, Logan Roof, Asrar Alahmadi, Regan M. Memmott, Jacob Kaufman, Kai He, Carolyn J. Presley, Peter G. Shields, David P. Carbone, Gregory A. Otterson, Jason Prosek, Dwight H. Owen
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Medicine
Subjects:
acute renal failure
immune checkpoint inhibitors
immunotherapy
non‐small‐cell lung cancer
pembrolizumab
survival
Online Access:https://doi.org/10.1002/cam4.71058
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https://doi.org/10.1002/cam4.71058

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