Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy

Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy

Abstract Background Prostate cancer (PCa) is commonly occurred among males worldwide and its prognosis could be influenced by biochemical recurrence (BCR). MicroRNAs (miRNAs) are functional regulators in carcinogenesis, and miR-221-3p was reported as one of the significant candidates deregulated in...

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Bibliographic Details
Main Authors: Dingchao Li, Jingang Jian, Manhong Shi, Zihao Chen, Anguo Zhao, Xuedong Wei, Yuhua Huang, Yalan Chen, Jianquan Hou, Yuxin Lin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Prostate cancer
miR-221-3p/KPNA2 regulation
Epithelial-to-mesenchymal transition
Biochemical recurrence
Systems biology modelling
Online Access:https://doi.org/10.1186/s12885-025-13444-1
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https://doi.org/10.1186/s12885-025-13444-1

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