Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review
Background. Pulmonary embolism (PE) is a medical emergency. Certain medications like oral contraceptives and hormone replacement therapies have been associated with PE. Clomiphene citrate is a selective estrogen receptor modulator, approved for treating infertility in females, but is being used as a...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/9987830 |
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| author | Vinod Solipuram Kishor Pokharel Temple Ihedinmah |
| author_facet | Vinod Solipuram Kishor Pokharel Temple Ihedinmah |
| author_sort | Vinod Solipuram |
| collection | DOAJ |
| description | Background. Pulmonary embolism (PE) is a medical emergency. Certain medications like oral contraceptives and hormone replacement therapies have been associated with PE. Clomiphene citrate is a selective estrogen receptor modulator, approved for treating infertility in females, but is being used as an off-label therapy in treating male hypogonadism. Very rarely, clomiphene can cause pulmonary embolism. Case Report. A 56-year-old gentleman presented with acute onset shortness of breath and chest discomfort. Upon further workup, he was found to have large volume pulmonary embolism. He was prescribed clomiphene citrate (CC) 2 years ago for hypogonadism. He was started on anticoagulation with improvement in his symptoms, and clomiphene was discontinued. Conclusion. Pulmonary embolism is a rare but potential complication of clomiphene therapy. In male patients with suspected hypogonadism, the risk of serious thromboembolic complications should be discussed before prescribing CC. Patients on CC have to be carefully monitored for serious side effects. |
| format | Article |
| id | doaj-art-7b709cf6aee74a13b8979b4431c9fd9d |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-7b709cf6aee74a13b8979b4431c9fd9d2025-02-03T01:08:58ZengWileyCase Reports in Endocrinology2090-65012090-651X2021-01-01202110.1155/2021/99878309987830Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature ReviewVinod Solipuram0Kishor Pokharel1Temple Ihedinmah2Department of Internal Medicine, Saint Agnes Hospital, Baltimore, MD 21229, USADepartment of Internal Medicine, Saint Agnes Hospital, Baltimore, MD 21229, USASaint George’s University, Great River, NY 11739, USABackground. Pulmonary embolism (PE) is a medical emergency. Certain medications like oral contraceptives and hormone replacement therapies have been associated with PE. Clomiphene citrate is a selective estrogen receptor modulator, approved for treating infertility in females, but is being used as an off-label therapy in treating male hypogonadism. Very rarely, clomiphene can cause pulmonary embolism. Case Report. A 56-year-old gentleman presented with acute onset shortness of breath and chest discomfort. Upon further workup, he was found to have large volume pulmonary embolism. He was prescribed clomiphene citrate (CC) 2 years ago for hypogonadism. He was started on anticoagulation with improvement in his symptoms, and clomiphene was discontinued. Conclusion. Pulmonary embolism is a rare but potential complication of clomiphene therapy. In male patients with suspected hypogonadism, the risk of serious thromboembolic complications should be discussed before prescribing CC. Patients on CC have to be carefully monitored for serious side effects.http://dx.doi.org/10.1155/2021/9987830 |
| spellingShingle | Vinod Solipuram Kishor Pokharel Temple Ihedinmah Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review Case Reports in Endocrinology |
| title | Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review |
| title_full | Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review |
| title_fullStr | Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review |
| title_full_unstemmed | Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review |
| title_short | Pulmonary Embolism as a Rare Complication of Clomiphene Therapy: A Case Report and Literature Review |
| title_sort | pulmonary embolism as a rare complication of clomiphene therapy a case report and literature review |
| url | http://dx.doi.org/10.1155/2021/9987830 |
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