Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis.
Gene-based association tests aggregate genotypes across multiple variants for each gene, providing an interpretable gene-level analysis framework for genome-wide association studies (GWAS). Early gene-based test applications often focused on rare coding variants; a more recent wave of gene-based met...
Saved in:
| Main Authors: | Corbin Quick, Xiaoquan Wen, Gonçalo Abecasis, Michael Boehnke, Hyun Min Kang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-12-01
|
| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009060&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Boosting Crowdsourced Annotation Accuracy: Small Loss Filtering and Augmentation-Driven Training
by: Yanming Fu, et al.
Published: (2024-01-01) -
Gene characterization index: assessing the depth of gene annotation.
by: Danielle Kemmer, et al.
Published: (2008-01-01) -
ACCURACY ANALYSIS OF THE GRADIENT BOOSTING METHOD WITH RANDOM ROTATIONS
by: Victor V. Kitov
Published: (2016-08-01) -
Boosting skin cancer diagnosis accuracy with ensemble approach
by: Priya Natha, et al.
Published: (2025-01-01) -
Functional annotation of the animal genomes: An integrated annotation resource for the horse.
by: Sichong Peng, et al.
Published: (2023-03-01)