Estimating the effect of tissue- and blood-derived cell reference matrices on deconvolving bulk transcriptomic datasets

Cell deconvolution is a widely used method to characterize the composition of the mixed cell population in bulk transcriptomic datasets. While tissue- and blood-derived cell reference matrices (CRMs) are commonly used, their impact on deconvolution accuracy has yet to be systematically evaluated. In...

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Bibliographic Details
Main Authors: Siqi Sun, Shweta Yadav, Mulini Pingili, Dan Chang, Jing Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
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Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025003216
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