Persistence and emergence of X4 virus in HIV infection

Approximately 50% of late-stage HIV patients develop CXCR4-tropic (X4) virus in addition to CCR5-tropic (R5) virus. X4 emergence occurs with a sharp decline in CD4+ T cell counts and accelerated time to AIDS. Why this phenotypic switch to X4 occurs is not well understood. Previously, we used numeri...

Full description

Saved in:
Bibliographic Details
Main Authors: Ariel D. Weinberger, Alan S. Perelson
Format: Article
Language:English
Published: AIMS Press 2011-03-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.605
Tags: Add Tag
No Tags, Be the first to tag this record!