Integrated genomics with refined cell-of-origin subtyping distinguishes subtype-specific mechanisms of treatment resistance and relapse in diffuse large B-cell lymphoma

Integrated genomics with refined cell-of-origin subtyping distinguishes subtype-specific mechanisms of treatment resistance and relapse in diffuse large B-cell lymphoma

Abstract Up to 40% of diffuse large B-cell lymphoma (DLBCL) patients do not experience a durable response to frontline immunochemotherapy, and prospective identification of high-risk cases that may benefit from personalized therapeutic management remains an unmet need. Molecular phenotyping techniqu...

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Main Authors: Janek S. Walker, Kerstin Wenzl, Joseph P. Novak, Matthew E. Stokes, Melissa A. Hopper, Abigail R. Dropik, Miranda S. Siminski, Allison M. Bock, Vivekananda Sarangi, Maria Ortiz, Nicholas Stong, C. Chris Huang, Matthew J. Maurer, Brian K. Link, Stephen M. Ansell, Thomas M. Habermann, Thomas E. Witzig, Rebecca L. King, Grzegorz Nowakowski, James R. Cerhan, Anita K. Gandhi, Anne J. Novak
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-025-01326-5
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https://doi.org/10.1038/s41408-025-01326-5

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