Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

Abstract Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro‐metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify key signalling events that drive metastatic evolution from the pancreas...

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Main Authors: Benoit Thibault, Fernanda Ramos‐Delgado, Elvire Pons‐Tostivint, Nicole Therville, Celia Cintas, Silvia Arcucci, Stephanie Cassant‐Sourdy, Gabriela Reyes‐Castellanos, Marie Tosolini, Amelie V Villard, Coralie Cayron, Romain Baer, Justine Bertrand‐Michel, Delphine Pagan, Dina Ferreira Da Mota, Hongkai Yan, Chiara Falcomatà, Fabrice Muscari, Barbara Bournet, Jean‐Pierre Delord, Ezra Aksoy, Alice Carrier, Pierre Cordelier, Dieter Saur, Celine Basset, Julie Guillermet‐Guibert
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
pancreatic cancer
phosphoinositide
PI3K isoforms
targeted therapy
tumour‐stroma dialog
Online Access:https://doi.org/10.15252/emmm.202013502
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https://doi.org/10.15252/emmm.202013502

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