Untargeted Lipidomic Biomarkers for Liver Cancer Diagnosis: A Tree-Based Machine Learning Model Enhanced by Explainable Artificial Intelligence

Untargeted Lipidomic Biomarkers for Liver Cancer Diagnosis: A Tree-Based Machine Learning Model Enhanced by Explainable Artificial Intelligence

<i>Background and Objectives</i>: Liver cancer ranks among the leading causes of cancer-related mortality, necessitating the development of novel diagnostic methods. Deregulated lipid metabolism, a hallmark of hepatocarcinogenesis, offers compelling prospects for biomarker identification...

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Bibliographic Details
Main Authors: Cemil Colak, Fatma Hilal Yagin, Abdulmohsen Algarni, Ali Algarni, Fahaid Al-Hashem, Luca Paolo Ardigò
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Medicina
Subjects:
liver cancer
lipidomics
biomarkers
machine learning
SHAP
precision medicine
Online Access:https://www.mdpi.com/1648-9144/61/3/405
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