Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence

Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence

Senescence is a state of irreversible growth arrest that can be induced in colorectal cancer (CRC). Developing drugs that can induce senescent CRC cells without promoting stemness can significantly improve treatment outcomes. Our study reveals a unique mechanism by which casticin (CAS) induces senes...

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Bibliographic Details
Main Authors: Tao Su, Zhiqiang Shi, Jincheng Tan, Linsheng Liu, Bingquan Zhao, Xueying Fan, Caiyan Wang, Hiu-Yee Kwan, Zhongqiu Liu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Casticin
Colorectal cancer
Tumor senescence
Rheb GTPase (Trp141), mTORC1-independent
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002804
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