Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice
Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimul...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/4960869 |
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| author | Gerardo Bernabé Ramírez-Rodríguez María del Ángel Ocaña-Fernández Leonardo Ortiz-López |
| author_facet | Gerardo Bernabé Ramírez-Rodríguez María del Ángel Ocaña-Fernández Leonardo Ortiz-López |
| author_sort | Gerardo Bernabé Ramírez-Rodríguez |
| collection | DOAJ |
| description | Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, the age of the cells that respond to a brief spatial exploration or a stressful situation produced by forced-swim stress in adult female Balb/C mice is still unknown. Here, we investigated the activation of newborn neurons after three (IdU) or six weeks (CldU) postlabelling with the expression of Arc in the same mice but exposed to different environmental stimuli. Mice housed in standard conditions showed an increase in the activation of CldU-labelled cells after two exposures to a brief spatial exploration but no increase in the activation of IdU-labelled cells compared with the control group. Additionally, we analysed neuronal activation in the DG of mice housed in standard conditions and further exposed to forced-swim stress. We found a decreased activation of IdU-labelled cells in mice exposed to forced-swim stress with increase number of CldU-labelled cells. Our results suggest that based on their time postlabelling, newly generated hippocampal neurons show a different response to several environmental stimuli. |
| format | Article |
| id | doaj-art-7a8e7e3cf6614d77ae0def91676c8c78 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7a8e7e3cf6614d77ae0def91676c8c782025-02-03T06:41:57ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/49608694960869Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C MiceGerardo Bernabé Ramírez-Rodríguez0María del Ángel Ocaña-Fernández1Leonardo Ortiz-López2Laboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, 14370 Mexico City, MexicoLaboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, 14370 Mexico City, MexicoLaboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, 14370 Mexico City, MexicoNeurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, the age of the cells that respond to a brief spatial exploration or a stressful situation produced by forced-swim stress in adult female Balb/C mice is still unknown. Here, we investigated the activation of newborn neurons after three (IdU) or six weeks (CldU) postlabelling with the expression of Arc in the same mice but exposed to different environmental stimuli. Mice housed in standard conditions showed an increase in the activation of CldU-labelled cells after two exposures to a brief spatial exploration but no increase in the activation of IdU-labelled cells compared with the control group. Additionally, we analysed neuronal activation in the DG of mice housed in standard conditions and further exposed to forced-swim stress. We found a decreased activation of IdU-labelled cells in mice exposed to forced-swim stress with increase number of CldU-labelled cells. Our results suggest that based on their time postlabelling, newly generated hippocampal neurons show a different response to several environmental stimuli.http://dx.doi.org/10.1155/2018/4960869 |
| spellingShingle | Gerardo Bernabé Ramírez-Rodríguez María del Ángel Ocaña-Fernández Leonardo Ortiz-López Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice Neural Plasticity |
| title | Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice |
| title_full | Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice |
| title_fullStr | Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice |
| title_full_unstemmed | Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice |
| title_short | Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice |
| title_sort | newly generated cells in the dentate gyrus differentially respond to brief spatial exploration and forced swim in adult female balb c mice |
| url | http://dx.doi.org/10.1155/2018/4960869 |
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