Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa

Abstract Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages. For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos. However, the causes of such abnormalities are unclear because no method to extract the segregated chromosomes from the blastome...

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Main Authors: Ikue Shibasaki, Hinata Sugiyama, Yuko Kamada, Hiroaki Nagatomo, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Tsuyoshi Kasai, Takashi Kohda, Teruhiko Wakayama
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07358-0
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