Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy

Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy

Protocadherin 19 (PCDH19) is an adhesion molecule involved in cell-cell interaction whose mutations cause a drug-resistant form of epilepsy, named PCDH19-Clustering Epilepsy (PCDH19-CE, MIM 300088). The mechanism by which altered PCDH19 function drive pathogenesis is not yet fully understood. Our pr...

Full description

Saved in:
Bibliographic Details
Main Authors: Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PCDH19
epilepsy
IPSC-derived neurons
microfilaments
microtubules
cytoskeletal dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1518533/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1518533/full

Similar Items