Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis
Objectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-𝜅B immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods. Immunohistochemical methodology...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2010/871356 |
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| author | Stylianos Kontos Georgia Sotiropoulou-Bonikou Athina Kominea Maria Melachrinou Eleni Balampani Dionysis Bonikos |
| author_facet | Stylianos Kontos Georgia Sotiropoulou-Bonikou Athina Kominea Maria Melachrinou Eleni Balampani Dionysis Bonikos |
| author_sort | Stylianos Kontos |
| collection | DOAJ |
| description | Objectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-𝜅B immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods. Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas). Results. COX-2 expression is increased in the cytoplasm of bladder cells, during loss of cell differentiation (𝑟s=0.61, 𝑃-value<.001) and in muscle invasive carcinomas (𝑃-value<.001). A strong positive association between tumor grade and nuclear expression of NF𝜅B has been established. A positive correlation between COX-2 and nuclear NF𝜅B immunoreactivity was observed. Conclusions. The possible coordinated upregulation of NF𝜅B and COX-2, during bladder carcinogenesis, indicates that agents inhibitors of these two molecules may represent a possible new treatment strategy, by virtue of their role in bladder carcinogenesis. |
| format | Article |
| id | doaj-art-7a580ac4dc044b5eb7e00e2c81885d97 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-7a580ac4dc044b5eb7e00e2c81885d972025-02-03T06:08:27ZengWileyAdvances in Urology1687-63691687-63772010-01-01201010.1155/2010/871356871356Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder CarcinogenesisStylianos Kontos0Georgia Sotiropoulou-Bonikou1Athina Kominea2Maria Melachrinou3Eleni Balampani4Dionysis Bonikos5Department of Pathology, Medical School, University of Patras, 26504 Rion, GreeceDepartment of Anatomy and Histology-Embryology, Medical School, University of Patras, 26504 Rion, GreeceDepartment of Pathology, Aegion General Hospital, 25100 Aegion, GreeceDepartment of Pathology, Medical School, University of Patras, 26504 Rion, GreeceDepartment of Microbiology, General Hospital of Nikaia, 18543 Peiraeus, GreeceDepartment of Pathology, Medical School, University of Patras, 26504 Rion, GreeceObjectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-𝜅B immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods. Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas). Results. COX-2 expression is increased in the cytoplasm of bladder cells, during loss of cell differentiation (𝑟s=0.61, 𝑃-value<.001) and in muscle invasive carcinomas (𝑃-value<.001). A strong positive association between tumor grade and nuclear expression of NF𝜅B has been established. A positive correlation between COX-2 and nuclear NF𝜅B immunoreactivity was observed. Conclusions. The possible coordinated upregulation of NF𝜅B and COX-2, during bladder carcinogenesis, indicates that agents inhibitors of these two molecules may represent a possible new treatment strategy, by virtue of their role in bladder carcinogenesis.http://dx.doi.org/10.1155/2010/871356 |
| spellingShingle | Stylianos Kontos Georgia Sotiropoulou-Bonikou Athina Kominea Maria Melachrinou Eleni Balampani Dionysis Bonikos Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis Advances in Urology |
| title | Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis |
| title_full | Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis |
| title_fullStr | Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis |
| title_full_unstemmed | Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis |
| title_short | Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis |
| title_sort | coordinated increased expression of cyclooxygenase2 and nuclear factor 𝜅b is a steady feature of urinary bladder carcinogenesis |
| url | http://dx.doi.org/10.1155/2010/871356 |
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