Clinical phenotypes and associated factors in knee osteoarthritis in an African black population
Objective: Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population. Methods: This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthri...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913125000068 |
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| author | Charles Sougué Malick Diallo Yannick Laurent Tchenadoyo Bayala Ismaël Ayouba Tinni Fulgence Kaboré Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo Patrick Wendpouiré Hamed Dakouré Dieu-Donné Ouedraogo |
| author_facet | Charles Sougué Malick Diallo Yannick Laurent Tchenadoyo Bayala Ismaël Ayouba Tinni Fulgence Kaboré Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo Patrick Wendpouiré Hamed Dakouré Dieu-Donné Ouedraogo |
| author_sort | Charles Sougué |
| collection | DOAJ |
| description | Objective: Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population. Methods: This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors. Results: A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the “osteoporotic” phenotype, 113 patients (35.2 %) exhibited the “metabolic” phenotype, 17 patients (5.3 %) exhibited the “genetic” phenotype, 24 patients (7.4 %) exhibited the “biomechanical” phenotype, and 15 patients (4.6 %) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034). Conclusion: The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years. |
| format | Article |
| id | doaj-art-7a4fa6c9f6a847258d38558302ec14af |
| institution | Kabale University |
| issn | 2665-9131 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-7a4fa6c9f6a847258d38558302ec14af2025-02-05T04:32:39ZengElsevierOsteoarthritis and Cartilage Open2665-91312025-03-0171100570Clinical phenotypes and associated factors in knee osteoarthritis in an African black populationCharles Sougué0Malick Diallo1Yannick Laurent Tchenadoyo Bayala2Ismaël Ayouba Tinni3Fulgence Kaboré4Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo5Patrick Wendpouiré Hamed Dakouré6Dieu-Donné Ouedraogo7Department of Internal Medicine, Sourou Sanou University Hospital, Bobo-Dioulasso, Burkina FasoDepartment of Orthopedics and Traumatology, Sourou Sanou University Hospital, Bobo-Dioulasso, Burkina FasoDepartment of Rheumatology, Bogodogo University Hospital, Ouagadougou, Burkina Faso; Corresponding author.Department of Rheumatology, Bogodogo University Hospital, Ouagadougou, Burkina FasoDepartment of Rheumatology, Bogodogo University Hospital, Ouagadougou, Burkina FasoDepartment of Rheumatology, Bogodogo University Hospital, Ouagadougou, Burkina FasoDepartment of Orthopedics and Traumatology, Sourou Sanou University Hospital, Bobo-Dioulasso, Burkina FasoDepartment of Rheumatology, Bogodogo University Hospital, Ouagadougou, Burkina FasoObjective: Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population. Methods: This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors. Results: A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the “osteoporotic” phenotype, 113 patients (35.2 %) exhibited the “metabolic” phenotype, 17 patients (5.3 %) exhibited the “genetic” phenotype, 24 patients (7.4 %) exhibited the “biomechanical” phenotype, and 15 patients (4.6 %) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034). Conclusion: The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.http://www.sciencedirect.com/science/article/pii/S2665913125000068Knee osteoarthritisClinical phenotypeAfrica |
| spellingShingle | Charles Sougué Malick Diallo Yannick Laurent Tchenadoyo Bayala Ismaël Ayouba Tinni Fulgence Kaboré Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo Patrick Wendpouiré Hamed Dakouré Dieu-Donné Ouedraogo Clinical phenotypes and associated factors in knee osteoarthritis in an African black population Osteoarthritis and Cartilage Open Knee osteoarthritis Clinical phenotype Africa |
| title | Clinical phenotypes and associated factors in knee osteoarthritis in an African black population |
| title_full | Clinical phenotypes and associated factors in knee osteoarthritis in an African black population |
| title_fullStr | Clinical phenotypes and associated factors in knee osteoarthritis in an African black population |
| title_full_unstemmed | Clinical phenotypes and associated factors in knee osteoarthritis in an African black population |
| title_short | Clinical phenotypes and associated factors in knee osteoarthritis in an African black population |
| title_sort | clinical phenotypes and associated factors in knee osteoarthritis in an african black population |
| topic | Knee osteoarthritis Clinical phenotype Africa |
| url | http://www.sciencedirect.com/science/article/pii/S2665913125000068 |
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