Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer
Calcified bilateral mediastinal lymph nodes are not common in malignant tumors. A 51-year-old woman presented to our hospital with a 20 mm nodule in the lower left lobe of the lung and extensive calcification in the bilateral mediastinal lymph nodes. Computed tomography indicated no calcification of...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2022/1160000 |
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| _version_ | 1832568006659538944 |
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| author | Keeya Sunata Tetsuo Tani Takahiko Ui Hidehiro Irie Yohei Funatsu Hidefumi Koh |
| author_facet | Keeya Sunata Tetsuo Tani Takahiko Ui Hidehiro Irie Yohei Funatsu Hidefumi Koh |
| author_sort | Keeya Sunata |
| collection | DOAJ |
| description | Calcified bilateral mediastinal lymph nodes are not common in malignant tumors. A 51-year-old woman presented to our hospital with a 20 mm nodule in the lower left lobe of the lung and extensive calcification in the bilateral mediastinal lymph nodes. Computed tomography indicated no calcification of the primary lesion. Immunohistochemical staining and fluorescent in situ hybridization detected an anaplastic lymphoma kinase (ALK) fusion. Treatment with alectinib, an ALK inhibitor, led to a significant reduction in tumor size and calcification in the lymph nodes. This case shows that different degrees of calcification can be associated with malignant tumors and may be reversible in some cases. |
| format | Article |
| id | doaj-art-7a2849e02814410e97ee5f9a15e75bb6 |
| institution | Kabale University |
| issn | 2090-6854 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-7a2849e02814410e97ee5f9a15e75bb62025-02-03T00:59:54ZengWileyCase Reports in Pulmonology2090-68542022-01-01202210.1155/2022/1160000Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung CancerKeeya Sunata0Tetsuo Tani1Takahiko Ui2Hidehiro Irie3Yohei Funatsu4Hidefumi Koh5Division of Pulmonary MedicineDivision of Pulmonary MedicineDivision of Pulmonary MedicineDivision of Pulmonary MedicineDivision of Pulmonary MedicineDivision of Pulmonary MedicineCalcified bilateral mediastinal lymph nodes are not common in malignant tumors. A 51-year-old woman presented to our hospital with a 20 mm nodule in the lower left lobe of the lung and extensive calcification in the bilateral mediastinal lymph nodes. Computed tomography indicated no calcification of the primary lesion. Immunohistochemical staining and fluorescent in situ hybridization detected an anaplastic lymphoma kinase (ALK) fusion. Treatment with alectinib, an ALK inhibitor, led to a significant reduction in tumor size and calcification in the lymph nodes. This case shows that different degrees of calcification can be associated with malignant tumors and may be reversible in some cases.http://dx.doi.org/10.1155/2022/1160000 |
| spellingShingle | Keeya Sunata Tetsuo Tani Takahiko Ui Hidehiro Irie Yohei Funatsu Hidefumi Koh Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer Case Reports in Pulmonology |
| title | Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer |
| title_full | Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer |
| title_fullStr | Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer |
| title_full_unstemmed | Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer |
| title_short | Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer |
| title_sort | remarkable differences in calcification between the primary tumor and metastatic lymph nodes in a patient with alk positive non small cell lung cancer |
| url | http://dx.doi.org/10.1155/2022/1160000 |
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