Molecular interaction assays in silico of crotapotin from Crotalus durissus terrificus against the molecular target trypanothione reductase from Leishmania braziliensis

Molecular interaction assays in silico of crotapotin from Crotalus durissus terrificus against the molecular target trypanothione reductase from Leishmania braziliensis

Abstract Background: Leishmaniasis is a neglected disease that mainly affects impoverished populations and receives limited attention from governments and research institutions. Current treatments are based on antimonial therapies, which present high toxicity and cause significant side effects, su...

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Main Authors: Jamile Mariano Macedo, Mateus Farias Souza, Anderson Maciel Lima, Aleff Ferreira Francisco, Anderson Makoto Kayano, Maria Elisabeth Moreira de Lima Gusmão, Erika Crhistina Santos de Araújo, Guilherme Henrique Marchi Salvador, Marcos Roberto de Mattos Fontes, Juliana Pavan Zuliani, Andreimar Martins Soares
Format: Article
Language:English
Published: SciELO 2025-04-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Snake venoms
Inhibition
Neglected tropical diseases
Molecular dynamics
Recombinant expression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992025000100306&lng=en&tlng=en
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