Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trialsResearch in context

Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trialsResearch in context

Summary: Background: Lassa fever (LF) is a zoonotic haemorrhagic disease caused by Lassa virus (LASV), which is endemic in West African countries. The multimammate rat is the main animal reservoir and its geographic range is expected to expand due to influences like climate change and land usage, a...

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Main Authors: Christopher L. Cooper, Gavin Morrow, Maoli Yuan, Thomas S. Postler, Maxwell L. Neal, Robert W. Cross, Courtney Woolsey, Krystle N. Agans, Viktoriya Borisevich, Ryan P. McNamara, Caroline Atyeo, Vicky Roy, Daritza Germosen, Fuxiang Hou, Shui L. Li, Lucia Reiserova, Yesle Choi, Aaron Wilson, Denise Wagner, Olivia Wallace-Selman, Alexei Carpov, Fuqiang Geng, Deborah J. Frederick, Joanne DeStefano, Anne M. Ercolini, Adrian S. Enriquez, Kathryn M. Hastie, Suzane Ramos da Silva, Eddy Sayeed, John W. Coleman, Andrew Kilianski, Galit Alter, Erica Ollmann Saphire, John D. Aitchison, Thomas W. Geisbert, Swati B. Gupta, Mark B. Feinberg, Christopher L. Parks
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:EBioMedicine
Subjects:
Lassa virus
Vesicular stomatitis virus vector
Clinical vaccine candidate
Neutralizing antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642500091X
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