Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies

Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies

BackgroundHigh-grade serous ovarian cancer (HGSOC), the predominant subtype of epithelial ovarian cancer, is frequently diagnosed at an advanced stage due to its nonspecific early symptoms. Despite standard treatments, including cytoreductive surgery and platinum-based chemotherapy, significant impr...

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Bibliographic Details
Main Authors: Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
high-grade serous ovarian cancer (HGSOC)
prognostic model
immunotherapy
molecular mechanisms
tumor microenvironment
multi-omics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500153/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500153/full

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