The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide

The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide

Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide is a new selective type II carbonic anhydrase inhibitor with local action through instillation into the eyes. For a complete pharmacokinetic study of this drug, it is necessary to detect and synthesize its metabolites for their syst...

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Main Authors: Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov
Format: Article
Language:English
Published: Belgorod National Research University 2024-11-01
Series:Research Results in Pharmacology
Subjects:
biotransformation
selective carbonic anhydrase ii inhibitor
hplc-ms/ms
n-hydroxysulfonamide
Online Access:https://rrpharmacology.ru/index.php/journal/article/view/498
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https://rrpharmacology.ru/index.php/journal/article/view/498

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