Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.

The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of sequence variation across the complex. Highly dupl...

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Main Authors: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti, Matthew E Hurles, C Andrew Stewart, Jennifer L Ashurst, Alexey M Atrazhev, Penny Coggill, Sophie Palmer, Jeff Almeida, Sarah Sims, Laurens G Wilming, Jane Rogers, Pieter J de Jong, Mary Carrington, John F Elliott, Stephen Sawcer, John A Todd, John Trowsdale, Stephan Beck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020009&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020009&type=printable

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