Host‐Microbial Cometabolite Ursodeoxycholic Acid Protects Against Poststroke Cognitive Impairment

Host‐Microbial Cometabolite Ursodeoxycholic Acid Protects Against Poststroke Cognitive Impairment

Background Poststroke cognitive impairment (PSCI) is a common residual disability after stroke, often underestimated and underdiagnosed. We previously found that ursodeoxycholic acid (UDCA), a host‐microbiota cometabolite, ameliorates brain damage in stroke mice. Based on these findings, we aimed to...

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Bibliographic Details
Main Authors: Xuxuan Gao, Feng Zhang, Jiafeng Zhang, Yu Ma, Yiting Deng, Jiaying Chen, Yueran Ren, Huidi Wang, Boxin Zhao, Yan He, Jia Yin
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
bile acid
cognitive impairment
gut microbiota
stroke
ursodeoxycholic acid
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.038862
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https://www.ahajournals.org/doi/10.1161/JAHA.124.038862

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