Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia.
Introduction. Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. Associated exacerbations and declining lung function contribute to increasing disa...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Nacional de Salud
2024-12-01
|
| Series: | Biomédica: revista del Instituto Nacional de Salud |
| Subjects: | |
| Online Access: | https://revistabiomedica.org/index.php/biomedica/article/view/7500 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592072938356736 |
|---|---|
| author | Andrés F. Zea-Vera Carlos Andrés Rodríguez Sebastián Giraldo Mario Alejandro Chacón Luis Fernando Guerrero Ricardo Mosquera Raúl Andrés Vallejo Fabio Samir Vargas María Andrea García María A. Rengifo Anilza Bonelo Maximiliano Parra |
| author_facet | Andrés F. Zea-Vera Carlos Andrés Rodríguez Sebastián Giraldo Mario Alejandro Chacón Luis Fernando Guerrero Ricardo Mosquera Raúl Andrés Vallejo Fabio Samir Vargas María Andrea García María A. Rengifo Anilza Bonelo Maximiliano Parra |
| author_sort | Andrés F. Zea-Vera |
| collection | DOAJ |
| description | Introduction. Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. Associated exacerbations and declining lung function contribute to increasing disability and mortality. There are no data about the prevalence of non-cystic fibrosis bronchiectasis etiologies in the Colombian population.
Objective. To investigate non-cystic fibrosis bronchiectasis etiology and clinical characteristics in adults evaluated in the southwest of Colombia.
Materials and methods. We conducted a cross-sectional, non-interventional study. Subjects diagnosed with non-cystic fibrosis bronchiectasis were referred to by their
healthcare providers and then enrolled between October 2018 and April 2021. Medical records and radiological studies were evaluated. Participants underwent laboratory tests, including complete blood count, serum immunoglobulin levels, and, in some cases, additional tests.
Results. We included 161 subjects. The average age was 50 years old, and 59% were females. Bronchiectasis etiology was identified in 84.6% of the cases. Postinfectious
(34.6%) and immune disorders (25.3%), represented by autoimmunity (13.6%) and immunodeficiency (11.7%), were the leading causes. Gender differences were noted in autoimmune (females: 18.8% versus males: 6.1%, p = 0.021) and immunodeficiency-related bronchiectasis (males: 21.2% versus females 5.2%, p = 0.002). Immunodeficiencies-associated bronchiectases were more frequent in subjects under 50 years of age, while chronic obstructive pulmonary disease-associated bronchiectases were common in subjects over 50 years of age.
Discussion. The etiologies of non-cystic fibrosis bronchiectasis in Colombia are diverse, exhibiting notable differences from other global regions. Serum immunoglobulin levels and clinical immunologist consultation should be prioritized in diagnosing patients with unclear bronchiectasis etiology, particularly those with recurrent sinopulmonary infections. |
| format | Article |
| id | doaj-art-791a64d79ff84f628da675807d8c8c1b |
| institution | Kabale University |
| issn | 0120-4157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Biomédica: revista del Instituto Nacional de Salud |
| spelling | doaj-art-791a64d79ff84f628da675807d8c8c1b2025-01-21T18:56:10ZengInstituto Nacional de SaludBiomédica: revista del Instituto Nacional de Salud0120-41572024-12-0144Sp. 2809310.7705/biomedica.75008955Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia.Andrés F. Zea-Vera0https://orcid.org/0000-0001-9127-3677Carlos Andrés Rodríguez1https://orcid.org/0009-0007-1358-4120Sebastián Giraldo2Mario Alejandro Chacón3https://orcid.org/0000-0001-6736-3015Luis Fernando Guerrero4https://orcid.org/0000-0002-8933-6939Ricardo Mosquera5https://orcid.org/0000-0003-2729-4769Raúl Andrés Vallejo6https://orcid.org/0000-0002-0692-5077Fabio Samir Vargas7https://orcid.org/0000-0002-3407-4011María Andrea García8María A. Rengifo9Anilza Bonelo10Maximiliano Parra11https://orcid.org/0009-0000-8842-8615Departamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, Colombia; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USADepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Medicina Interna, Facultad de Salud, Universidad del Valle, Cali, Colombiaervicio de Neumología, Clínica Neumológica del Pacífico, Cali, ColombiaDepartamento de Medicina Interna, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, Colombia; Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USADepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, ColombiaDepartamento de Medicina Interna, Facultad de Salud, Universidad del Valle, Cali, ColombiaIntroduction. Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. Associated exacerbations and declining lung function contribute to increasing disability and mortality. There are no data about the prevalence of non-cystic fibrosis bronchiectasis etiologies in the Colombian population. Objective. To investigate non-cystic fibrosis bronchiectasis etiology and clinical characteristics in adults evaluated in the southwest of Colombia. Materials and methods. We conducted a cross-sectional, non-interventional study. Subjects diagnosed with non-cystic fibrosis bronchiectasis were referred to by their healthcare providers and then enrolled between October 2018 and April 2021. Medical records and radiological studies were evaluated. Participants underwent laboratory tests, including complete blood count, serum immunoglobulin levels, and, in some cases, additional tests. Results. We included 161 subjects. The average age was 50 years old, and 59% were females. Bronchiectasis etiology was identified in 84.6% of the cases. Postinfectious (34.6%) and immune disorders (25.3%), represented by autoimmunity (13.6%) and immunodeficiency (11.7%), were the leading causes. Gender differences were noted in autoimmune (females: 18.8% versus males: 6.1%, p = 0.021) and immunodeficiency-related bronchiectasis (males: 21.2% versus females 5.2%, p = 0.002). Immunodeficiencies-associated bronchiectases were more frequent in subjects under 50 years of age, while chronic obstructive pulmonary disease-associated bronchiectases were common in subjects over 50 years of age. Discussion. The etiologies of non-cystic fibrosis bronchiectasis in Colombia are diverse, exhibiting notable differences from other global regions. Serum immunoglobulin levels and clinical immunologist consultation should be prioritized in diagnosing patients with unclear bronchiectasis etiology, particularly those with recurrent sinopulmonary infections.https://revistabiomedica.org/index.php/biomedica/article/view/7500bronchiectasispositron-emission tomographythoraxagammaglobulinemiatuberculosisalpha- 1-antitrypsinpulmonary disease, chronic obstructivelungadults |
| spellingShingle | Andrés F. Zea-Vera Carlos Andrés Rodríguez Sebastián Giraldo Mario Alejandro Chacón Luis Fernando Guerrero Ricardo Mosquera Raúl Andrés Vallejo Fabio Samir Vargas María Andrea García María A. Rengifo Anilza Bonelo Maximiliano Parra Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. Biomédica: revista del Instituto Nacional de Salud bronchiectasis positron-emission tomography thorax agammaglobulinemia tuberculosis alpha- 1-antitrypsin pulmonary disease, chronic obstructive lung adults |
| title | Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. |
| title_full | Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. |
| title_fullStr | Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. |
| title_full_unstemmed | Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. |
| title_short | Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. |
| title_sort | infections autoimmunity and immunodeficiencies are the leading etiologies of non cystic fibrosis bronchiectasis in adults from the southwest of colombia |
| topic | bronchiectasis positron-emission tomography thorax agammaglobulinemia tuberculosis alpha- 1-antitrypsin pulmonary disease, chronic obstructive lung adults |
| url | https://revistabiomedica.org/index.php/biomedica/article/view/7500 |
| work_keys_str_mv | AT andresfzeavera infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT carlosandresrodriguez infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT sebastiangiraldo infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT marioalejandrochacon infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT luisfernandoguerrero infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT ricardomosquera infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT raulandresvallejo infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT fabiosamirvargas infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT mariaandreagarcia infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT mariaarengifo infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT anilzabonelo infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia AT maximilianoparra infectionsautoimmunityandimmunodeficienciesaretheleadingetiologiesofnoncysticfibrosisbronchiectasisinadultsfromthesouthwestofcolombia |