Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

IntroductionTau pathology in sporadic Alzheimer’s disease (AD) follows a distinct pattern, beginning in the entorhinal cortex (ERC) and spreading to interconnected brain regions. Early-stage tau pathology, characterized by soluble phosphorylated tau, is difficult to study in human brains post-mortem...

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Bibliographic Details
Main Authors: Shveta Bathla, Dibyadeep Datta, Dinara Bolat, Elizabeth Woo, Alvaro Duque, Jon I. Arellano, Amy F. T. Arnsten, Angus C. Nairn
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
entorhinal cortex
tau pathology
cAMP-calcium signaling
Alzheimer’s disease
calpain-2
GCPII
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1549770/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1549770/full

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