Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice

Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice

Exposure to ionizing radiation disrupts metabolic pathways and causes oxidative stress, which can lead to organ damage. In this study, urinary metabolites from mice exposed to high-dose and low-dose whole-body irradiation (WBI HDR, WBI LDR) or partial-body irradiation (PBI BM2.5) were analyzed using...

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Main Authors: Yaoxiang Li, Shivani Bansal, Baldev Singh, Meth M. Jayatilake, William Klotzbier, Marjan Boerma, Mi-Heon Lee, Jacob Hack, Keisuke S. Iwamoto, Dörthe Schaue, Amrita K. Cheema
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antioxidants
Subjects:
radiation exposure
whole-body irradiation
partial-body irradiation
metabolomics
urine metabolomics
pathway analysis
Online Access:https://www.mdpi.com/2076-3921/14/1/24
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