Drugs as a cause of perforating dermatoses – a literature review

Perforating dermatoses represents a diverse group of skin diseases characterised by extrusion of dermal materials through the skin. Perforating dermatoses are grouped according to the types of eliminated material and clinical features into the following: reactive perforating collagenosis, elastosis...

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Main Authors: Lidia Mądrzak, Izabela Staniszewska, Arkadiusz Moskwa, Agnieszka Kalińska-Bienias
Format: Article
Language:English
Published: Termedia Publishing House 2024-11-01
Series:Przegląd Dermatologiczny
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Online Access:https://www.termedia.pl/Drugs-as-a-cause-of-perforating-dermatoses-a-literature-review,56,55058,1,1.html
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author Lidia Mądrzak
Izabela Staniszewska
Arkadiusz Moskwa
Agnieszka Kalińska-Bienias
author_facet Lidia Mądrzak
Izabela Staniszewska
Arkadiusz Moskwa
Agnieszka Kalińska-Bienias
author_sort Lidia Mądrzak
collection DOAJ
description Perforating dermatoses represents a diverse group of skin diseases characterised by extrusion of dermal materials through the skin. Perforating dermatoses are grouped according to the types of eliminated material and clinical features into the following: reactive perforating collagenosis, elastosis perforans serpiginous, perforating folliculitis, and Kyrle’s disease. We conducted a literature review to investigate the associations between perforating dermatoses and drugs. Perforating dermatoses can be induced by the molecularly targeted therapy drugs (sorafenib, nilotinib, dasatinib, erlotinib, gefitinib, vemurafenib, lenvatinib, sirolimus, bevacizumab, necitumumab, panitumumab, cetuximab, bendamustine-rituximab, terepril), monoclonal antibodies (infliximab, etanercept, ranibizumab, natalizumab), as well as immunomodulatory imide drugs (lenalidomide, leflunomide), antiretroviral drugs (indinavir, telaprevir) and penicillamine. Sorafenib is the most common molecularly targeted therapy drug which was described as a cause of perforating dermatoses. The mechanisms responsible for inducing perforating dermatoses with drugs are unknown.
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2084-9893
language English
publishDate 2024-11-01
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series Przegląd Dermatologiczny
spelling doaj-art-78a0076de7c842ce9aa239f8f2e9acca2025-01-27T11:10:08ZengTermedia Publishing HousePrzegląd Dermatologiczny0033-25262084-98932024-11-01111320922110.5114/dr.2024.14465255058Drugs as a cause of perforating dermatoses – a literature reviewLidia MądrzakIzabela StaniszewskaArkadiusz MoskwaAgnieszka Kalińska-BieniasPerforating dermatoses represents a diverse group of skin diseases characterised by extrusion of dermal materials through the skin. Perforating dermatoses are grouped according to the types of eliminated material and clinical features into the following: reactive perforating collagenosis, elastosis perforans serpiginous, perforating folliculitis, and Kyrle’s disease. We conducted a literature review to investigate the associations between perforating dermatoses and drugs. Perforating dermatoses can be induced by the molecularly targeted therapy drugs (sorafenib, nilotinib, dasatinib, erlotinib, gefitinib, vemurafenib, lenvatinib, sirolimus, bevacizumab, necitumumab, panitumumab, cetuximab, bendamustine-rituximab, terepril), monoclonal antibodies (infliximab, etanercept, ranibizumab, natalizumab), as well as immunomodulatory imide drugs (lenalidomide, leflunomide), antiretroviral drugs (indinavir, telaprevir) and penicillamine. Sorafenib is the most common molecularly targeted therapy drug which was described as a cause of perforating dermatoses. The mechanisms responsible for inducing perforating dermatoses with drugs are unknown.https://www.termedia.pl/Drugs-as-a-cause-of-perforating-dermatoses-a-literature-review,56,55058,1,1.htmlperforating dermatoses molecularly targeted therapy kinase inhibitors monoclonal antibodies acquired perforating dermatoses
spellingShingle Lidia Mądrzak
Izabela Staniszewska
Arkadiusz Moskwa
Agnieszka Kalińska-Bienias
Drugs as a cause of perforating dermatoses – a literature review
Przegląd Dermatologiczny
perforating dermatoses
molecularly targeted therapy
kinase inhibitors
monoclonal antibodies
acquired perforating dermatoses
title Drugs as a cause of perforating dermatoses – a literature review
title_full Drugs as a cause of perforating dermatoses – a literature review
title_fullStr Drugs as a cause of perforating dermatoses – a literature review
title_full_unstemmed Drugs as a cause of perforating dermatoses – a literature review
title_short Drugs as a cause of perforating dermatoses – a literature review
title_sort drugs as a cause of perforating dermatoses a literature review
topic perforating dermatoses
molecularly targeted therapy
kinase inhibitors
monoclonal antibodies
acquired perforating dermatoses
url https://www.termedia.pl/Drugs-as-a-cause-of-perforating-dermatoses-a-literature-review,56,55058,1,1.html
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AT izabelastaniszewska drugsasacauseofperforatingdermatosesaliteraturereview
AT arkadiuszmoskwa drugsasacauseofperforatingdermatosesaliteraturereview
AT agnieszkakalinskabienias drugsasacauseofperforatingdermatosesaliteraturereview