Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol

Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol

Abstract Background There are several major challenges limiting our ability to test analgesic efficacy for treatment of neonatal pain, and progress in analgesic drug studies in neonates has stalled. One significant issue is the reliance of clinical pain assessments on traditional behavioural and vit...

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Main Authors: Luke Baxter, Marianne van der Vaart, Maria M. Cobo, Patricia Y. Gunawan, Karel Allegaert, Jonathan M. Davis, Mark Turner, Robert M. Ward, Edress Darsey, James P. Sheppard, Aomesh Bhatt, John van den Anker, An N. Massaro, Ramona L. Walls, Laura S. Song, Kanwaljit Singh, INC Pain Working Group, Rebeccah Slater
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Systematic Reviews
Subjects:
Neonate
Pain
Brain
Electroencephalography
Biomarkers
Meta-analysis
Online Access:https://doi.org/10.1186/s13643-025-02890-4
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https://doi.org/10.1186/s13643-025-02890-4

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