Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies

Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies

Genomic instability plays a crucial role in oncogenesis. Somatically acquired mutations can disable some genes and inappropriately activate others. In addition, chromosomal rearrangements can amplify, delete, or even fuse genes, altering their functions and contributing to malignant phenotypes. Usin...

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Bibliographic Details
Main Authors: J. Kimble Frazer, Lance A. Batchelor, Diana F. Bradley, Kim H. Brown, Kimberly P. Dobrinski, Charles Lee, Nikolaus S. Trede
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2012/627920
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