TRDMT1 methyltransferase gene knockout attenuates STING-based cell death signaling during self-extracellular RNA-mediated response in drug-induced senescent osteosarcoma cells

TRDMT1 methyltransferase gene knockout attenuates STING-based cell death signaling during self-extracellular RNA-mediated response in drug-induced senescent osteosarcoma cells

Abstract Under stress conditions, endogenous biomolecules such as nucleic acids or proteins can be released from damaged cells and considered as damage-associated molecular patterns (DAMPs) activating innate immune system and context-dependent responses. In the present study, self-extracellular RNA...

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Main Authors: Gabriela Betlej, Anna Deręgowska, Maciej Wnuk, Dominika Błoniarz, Tomasz Szmatoła, Katarzyna Klimczak, Jagoda Adamczyk-Grochala, Julia Świętoń, Anna Lewińska
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
Self-extracellular RNA sensing
TRDMT1
STING
Drug-induced senescence, osteosarcoma
Online Access:https://doi.org/10.1007/s00018-025-05835-1
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https://doi.org/10.1007/s00018-025-05835-1

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