Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis.
<h4>Background</h4>Antimicrobial-resistant (AMR) bacterial infection is a significant global threat to the healthcare systems. Pseudomonas aeruginosa, the leading infectious agent in the healthcare setting is now one of the major threats due to AMR. A comprehensive understanding of the m...
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2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0308946 |
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| author | Zelalem Asmare Melese Abate Reta Yalewayker Gashaw Ermias Getachew Assefa Sisay Muluken Gashaw Ephrem Tamrat Atitegeb Abera Kidie Wagaw Abebe Tadesse Misganaw Agenagnew Ashagre Zelalem Dejazmach Getinet Kumie Marye Nigatie Sisay Ayana Abdu Jemal Solomon Gedfie Woldeteklehaymanot Kassahun Mulat Awoke Kassa Selamyhun Tadesse Biruk Beletew Abate |
| author_facet | Zelalem Asmare Melese Abate Reta Yalewayker Gashaw Ermias Getachew Assefa Sisay Muluken Gashaw Ephrem Tamrat Atitegeb Abera Kidie Wagaw Abebe Tadesse Misganaw Agenagnew Ashagre Zelalem Dejazmach Getinet Kumie Marye Nigatie Sisay Ayana Abdu Jemal Solomon Gedfie Woldeteklehaymanot Kassahun Mulat Awoke Kassa Selamyhun Tadesse Biruk Beletew Abate |
| author_sort | Zelalem Asmare |
| collection | DOAJ |
| description | <h4>Background</h4>Antimicrobial-resistant (AMR) bacterial infection is a significant global threat to the healthcare systems. Pseudomonas aeruginosa, the leading infectious agent in the healthcare setting is now one of the major threats due to AMR. A comprehensive understanding of the magnitude of AMR, particularly highly public health important pathogens such as P. aeruginosa, is necessary for the management of infections based on local information.<h4>Objective</h4>This systematic review and meta-analysis aimed to determine the country-wide AMR of P. aeruginosa.<h4>Methods</h4>Systematic searches were performed to retrieve articles from PubMed, Scopus, Web of Science, ScienceDirect electronic databases, Google Scholar search engine, and repository registrars from 2015 to 31st December 2023. Twenty-three studies that provided important data on AMR in P. aeruginosa were systematically reviewed and analyzed to determine the country-wide magnitude of P. aeruginosa AMR profile from healthcare-associated infections. AMR of P. aeruginosa to 10 different antibiotics were extracted separately into Microsoft Excel and analyzed using STATA 17.0. Cohen's kappa was computed to determine the agreement between reviewers, the Inverse of variance (I2) was used to evaluate heterogeneity across studies, and Egger's test to identify publication bias. A random effect model was used to determine the pooled resistance to each antibiotic. Subgroup analysis was performed by infection type and year of publication.<h4>Results</h4>This systematic review and meta-analysis revealed that the pooled prevalence of P. aeruginosa in clinical specimens associated with HAI was 4.38%(95%CI: 3.00-5.76). The pooled prevalence of AMR in P. aeruginosa for different antibiotics varies, ranging from 20.9% (95%CI: 6.2-35.8) for amikacin to 98.72% (95%CI: 96.39-101.4) for ceftriaxone. The pooled resistance was higher for ceftriaxone (98.72%), Trimethoprim-sulfamethoxazole (75.41), and amoxicillin-clavulanic acid (91.2). In contrast relatively lower AMR were observed for amikacin (20.9%) and meropenem (28.64%). The pooled multi-drug resistance (MDR) in P. aeruginosa was 80.5% (95%CI: 66.25-93.84). Upon subgroup analysis by infection types and year of publication, P. aeruginosa isolated from healthcare-associated infections exhibited higher resistance to ceftazidime (94.72%) compared to isolates from mixed types of healthcare-associated infections (70.84%) and surgical site infections (57.84%). Antimicrobial resistance in gentamicin was higher during the periods of 2018-2020 (73.96%), while comparatively lower during 2021-2023 (42.69%) and 2015-2017 (29.82%).<h4>Conclusions</h4>Significantly high AMR and MDR were observed from this systematic review and meta-analysis. AMR obtained from this systematic review and meta-analysis urges the need for improved infection control, antimicrobial stewardship practices, and strengthened surveillance systems to control the spread of AMR and ensure effective treatment of P. aeruginosa infections.<h4>Protocol registration</h4>This systematic review and meta-analysis was registered on PROSPERO (Registration ID: CRD42024518145). |
| format | Article |
| id | doaj-art-783c9d7a6d5a4370b9c46fe0269aaa0a |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-783c9d7a6d5a4370b9c46fe0269aaa0a2025-02-05T05:32:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01198e030894610.1371/journal.pone.0308946Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis.Zelalem AsmareMelese Abate RetaYalewayker GashawErmias GetachewAssefa SisayMuluken GashawEphrem TamratAtitegeb Abera KidieWagaw AbebeTadesse MisganawAgenagnew AshagreZelalem DejazmachGetinet KumieMarye NigatieSisay AyanaAbdu JemalSolomon GedfieWoldeteklehaymanot KassahunMulat Awoke KassaSelamyhun TadesseBiruk Beletew Abate<h4>Background</h4>Antimicrobial-resistant (AMR) bacterial infection is a significant global threat to the healthcare systems. Pseudomonas aeruginosa, the leading infectious agent in the healthcare setting is now one of the major threats due to AMR. A comprehensive understanding of the magnitude of AMR, particularly highly public health important pathogens such as P. aeruginosa, is necessary for the management of infections based on local information.<h4>Objective</h4>This systematic review and meta-analysis aimed to determine the country-wide AMR of P. aeruginosa.<h4>Methods</h4>Systematic searches were performed to retrieve articles from PubMed, Scopus, Web of Science, ScienceDirect electronic databases, Google Scholar search engine, and repository registrars from 2015 to 31st December 2023. Twenty-three studies that provided important data on AMR in P. aeruginosa were systematically reviewed and analyzed to determine the country-wide magnitude of P. aeruginosa AMR profile from healthcare-associated infections. AMR of P. aeruginosa to 10 different antibiotics were extracted separately into Microsoft Excel and analyzed using STATA 17.0. Cohen's kappa was computed to determine the agreement between reviewers, the Inverse of variance (I2) was used to evaluate heterogeneity across studies, and Egger's test to identify publication bias. A random effect model was used to determine the pooled resistance to each antibiotic. Subgroup analysis was performed by infection type and year of publication.<h4>Results</h4>This systematic review and meta-analysis revealed that the pooled prevalence of P. aeruginosa in clinical specimens associated with HAI was 4.38%(95%CI: 3.00-5.76). The pooled prevalence of AMR in P. aeruginosa for different antibiotics varies, ranging from 20.9% (95%CI: 6.2-35.8) for amikacin to 98.72% (95%CI: 96.39-101.4) for ceftriaxone. The pooled resistance was higher for ceftriaxone (98.72%), Trimethoprim-sulfamethoxazole (75.41), and amoxicillin-clavulanic acid (91.2). In contrast relatively lower AMR were observed for amikacin (20.9%) and meropenem (28.64%). The pooled multi-drug resistance (MDR) in P. aeruginosa was 80.5% (95%CI: 66.25-93.84). Upon subgroup analysis by infection types and year of publication, P. aeruginosa isolated from healthcare-associated infections exhibited higher resistance to ceftazidime (94.72%) compared to isolates from mixed types of healthcare-associated infections (70.84%) and surgical site infections (57.84%). Antimicrobial resistance in gentamicin was higher during the periods of 2018-2020 (73.96%), while comparatively lower during 2021-2023 (42.69%) and 2015-2017 (29.82%).<h4>Conclusions</h4>Significantly high AMR and MDR were observed from this systematic review and meta-analysis. AMR obtained from this systematic review and meta-analysis urges the need for improved infection control, antimicrobial stewardship practices, and strengthened surveillance systems to control the spread of AMR and ensure effective treatment of P. aeruginosa infections.<h4>Protocol registration</h4>This systematic review and meta-analysis was registered on PROSPERO (Registration ID: CRD42024518145).https://doi.org/10.1371/journal.pone.0308946 |
| spellingShingle | Zelalem Asmare Melese Abate Reta Yalewayker Gashaw Ermias Getachew Assefa Sisay Muluken Gashaw Ephrem Tamrat Atitegeb Abera Kidie Wagaw Abebe Tadesse Misganaw Agenagnew Ashagre Zelalem Dejazmach Getinet Kumie Marye Nigatie Sisay Ayana Abdu Jemal Solomon Gedfie Woldeteklehaymanot Kassahun Mulat Awoke Kassa Selamyhun Tadesse Biruk Beletew Abate Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. PLoS ONE |
| title | Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. |
| title_full | Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. |
| title_fullStr | Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. |
| title_full_unstemmed | Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. |
| title_short | Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. |
| title_sort | antimicrobial resistance profile of pseudomonas aeruginosa clinical isolates from healthcare associated infections in ethiopia a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0308946 |
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