A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli
Abstract Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highligh...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00078-3 |
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| author | Mallory Wright Mandeep Kaur Laura K. Thompson Georgina Cox |
| author_facet | Mallory Wright Mandeep Kaur Laura K. Thompson Georgina Cox |
| author_sort | Mallory Wright |
| collection | DOAJ |
| description | Abstract Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E. coli. |
| format | Article |
| id | doaj-art-78293d44e0434781995deec54c252673 |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-78293d44e0434781995deec54c2526732025-01-26T12:54:17ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-01-013111110.1038/s44259-025-00078-3A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coliMallory Wright0Mandeep Kaur1Laura K. Thompson2Georgina Cox3College of Biological Sciences, Department of Molecular and Cellular Biology, University of GuelphCollege of Biological Sciences, Department of Molecular and Cellular Biology, University of GuelphCollege of Biological Sciences, Department of Molecular and Cellular Biology, University of GuelphCollege of Biological Sciences, Department of Molecular and Cellular Biology, University of GuelphAbstract Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E. coli.https://doi.org/10.1038/s44259-025-00078-3 |
| spellingShingle | Mallory Wright Mandeep Kaur Laura K. Thompson Georgina Cox A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli npj Antimicrobials and Resistance |
| title | A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli |
| title_full | A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli |
| title_fullStr | A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli |
| title_full_unstemmed | A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli |
| title_short | A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli |
| title_sort | historical perspective on the multifunctional outer membrane channel protein tolc in escherichia coli |
| url | https://doi.org/10.1038/s44259-025-00078-3 |
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