Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway

Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway

Background: Osteoarthritis (OA) is the most common degenerative joint disease, characterized by cartilage deterioration, which is closely associated with chondrocyte ferroptosis. The aim of this study was to investigate the role and mechanism of previously unexplored gene, growth factor independence...

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Main Authors: Xiaoyu Jin, Xunhao Wang, Siyu Xu, Nuo Xu, Ziwei Wang, Chunqing Hu, Wei Liu, Zhaofeng Zhang, Xiyu Liu, Jingjing Fan, Ruiyang Jiang, Rui Wu, Zhongyang Lv, Dongquan Shi
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Osteoarthritis
Ferroptosis
Chondrocyte
Gfi1
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25001160
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