ALVAC-prime and monomeric gp120 protein boost induces distinct HIV-1 specific humoral and cellular responses compared with adenovirus-prime and trimeric gp140 protein boost.

ALVAC-prime and monomeric gp120 protein boost induces distinct HIV-1 specific humoral and cellular responses compared with adenovirus-prime and trimeric gp140 protein boost.

Although clade-specific and cross-clade mosaic prime-boost HIV-1 vaccine regimens were advanced to the HVTN 702 and HVTN 705 efficacy trials, neither regimen prevented HIV acquisition. The respective Phase 1/2a studies, HVTN 100 (NCT02404311) and HVTN 117/HPX2004 (NCT02788045), provided rich immunol...

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Main Authors: Leigh H Fisher, Erica Lazarus, Chenchen Yu, Zoe Moodie, Daniel J Stieh, Nicole Yates, Lu Zhang, Sheetal Sawant, Stephen C De Rosa, Kristen W Cohen, Daryl Morris, Shannon Grant, April Randhawa, Maurine D Miner, Jenny Hendriks, Frank Wegmann, Katherine M Gill, Fatima Laher, Linda-Gail Bekker, Glenda E Gray, Lawrence Corey, M Juliana McElrath, Troy Martin, Peter B Gilbert, Georgia Tomaras, Stephen R Walsh, Lindsey R Baden, HVTN 100, HVTN 117/HPX2004 study teams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLOS Global Public Health
Online Access:https://doi.org/10.1371/journal.pgph.0004250
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https://doi.org/10.1371/journal.pgph.0004250

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