In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors.

In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors.

The current study has investigated the use of decellularised, demineralised bone extracellular matrix (ECM) hydrogel constructs for in vivo tissue mineralisation and bone formation. Stro-1-enriched human bone marrow stromal cells were incorporated together with select growth factors including VEGF,...

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Main Authors: David Gothard, Emma L Smith, Janos M Kanczler, Cameron R Black, Julia A Wells, Carol A Roberts, Lisa J White, Omar Qutachi, Heather Peto, Hassan Rashidi, Luis Rojo, Molly M Stevens, Alicia J El Haj, Felicity R A J Rose, Kevin M Shakesheff, Richard O C Oreffo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0145080
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https://doi.org/10.1371/journal.pone.0145080

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