Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study

Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study

Objectives: Cellular senescence, characterized by a marked and multifactorial senescence-associated secretory phenotype (SASP), is a potential unifying mechanism of aging and chronic disease. Most studies of the SASP have focused on frailty and other functional outcomes. Senescent cells have been de...

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Bibliographic Details
Main Authors: Michelle M. Mielke, Roger A. Fielding, Elizabeth J. Atkinson, Zaira Aversa, Marissa J. Schafer, Steven R. Cummings, Marco Pahor, Christiaan Leeuwenburgh, Nathan K. LeBrasseur
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:The Journal of Nutrition, Health and Aging
Subjects:
Cognition
SASP
Mobility disability
Myeloperoxidase
Matrix metalloproteinase 7
Online Access:http://www.sciencedirect.com/science/article/pii/S1279770725000521
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