HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo–YAP pathway activation

HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo–YAP pathway activation

Abstract Background Sleep apnea syndrome (SAS) is associated with hypertension and vascular remodeling. Hypoxia-inducible factor-1α (HIF-1α) and the Hippo–YAP pathway are implicated in these processes, but their specific roles remain unclear. This study investigated the HIF-1α/Hippo-YAP pathway in S...

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Bibliographic Details
Main Authors: Shoude Zhang, Yuan Zhao, Zhanwei Dong, Mao Jin, Ying Lu, Mina Xu, Hong Pan, Guojin Zhou, Mang Xiao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Sleep apnea syndrome
HIF-1α, Hippo
YAP
Vascular remodeling
Inflammation
Online Access:https://doi.org/10.1186/s10020-024-00987-5
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https://doi.org/10.1186/s10020-024-00987-5

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