Three-Axis Model for Atg Recruitment in Autophagy against Salmonella
Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella-containing vacuole (SCV). In this paper,...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/389562 |
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| _version_ | 1832545515115380736 |
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| author | Takeshi Noda Shun Kageyama Naonobu Fujita Tamotsu Yoshimori |
| author_facet | Takeshi Noda Shun Kageyama Naonobu Fujita Tamotsu Yoshimori |
| author_sort | Takeshi Noda |
| collection | DOAJ |
| description | Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella-containing vacuole (SCV). In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella. The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex. In the absence of Atg9L1, FIP200, and PI3-kinase activity, LC3 is still recruited to the vicinity of Salmonella. We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane. There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atg16L complex. |
| format | Article |
| id | doaj-art-7738e1a3253f45eda1ff43477bbceaa5 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-7738e1a3253f45eda1ff43477bbceaa52025-02-03T07:25:34ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/389562389562Three-Axis Model for Atg Recruitment in Autophagy against SalmonellaTakeshi Noda0Shun Kageyama1Naonobu Fujita2Tamotsu Yoshimori3Department of Genetics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanProtein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0007, JapanDepartment of Genetics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Genetics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanSalmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella-containing vacuole (SCV). In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella. The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex. In the absence of Atg9L1, FIP200, and PI3-kinase activity, LC3 is still recruited to the vicinity of Salmonella. We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane. There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atg16L complex.http://dx.doi.org/10.1155/2012/389562 |
| spellingShingle | Takeshi Noda Shun Kageyama Naonobu Fujita Tamotsu Yoshimori Three-Axis Model for Atg Recruitment in Autophagy against Salmonella International Journal of Cell Biology |
| title | Three-Axis Model for Atg Recruitment in Autophagy against Salmonella |
| title_full | Three-Axis Model for Atg Recruitment in Autophagy against Salmonella |
| title_fullStr | Three-Axis Model for Atg Recruitment in Autophagy against Salmonella |
| title_full_unstemmed | Three-Axis Model for Atg Recruitment in Autophagy against Salmonella |
| title_short | Three-Axis Model for Atg Recruitment in Autophagy against Salmonella |
| title_sort | three axis model for atg recruitment in autophagy against salmonella |
| url | http://dx.doi.org/10.1155/2012/389562 |
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