MTFAP: a comprehensive platform for predicting and analyzing master transcription factors

MTFAP: a comprehensive platform for predicting and analyzing master transcription factors

Abstract Master transcription factors (MTFs) activate gene expression in pluripotent embryonic stem cells (ESCs) by binding to enhancers and super-enhancers, which precisely control ESC fate. Compelling evidence reveals a strong correlation between the operation of MTFs and the initiation and progre...

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Main Authors: Jianyuan Zhou, Haojie Yu, Chunhui Lou, Min Yang, Yanshang Li, Qian Yang, Shuhan Li, Chunwang Ji, Song Li, Shuang Wang, Haotian Cao, Xuecang Li, Lian Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Master transcription factors
Core regulatory circuit
Bulk RNA-seq
Single-cell RNA-seq
Online Access:https://doi.org/10.1038/s41598-024-83686-9
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https://doi.org/10.1038/s41598-024-83686-9

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