Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract
The mucosal surface of the female genital tract is a complex biosystem, which provides a barrier against the outside world and participates in both innate and acquired immune defense systems. This mucosal compartment has adapted to a dynamic, non-sterile environment challenged by a variety of antige...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/976024 |
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| _version_ | 1832551885908738048 |
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| author | Kaei Nasu Hisashi Narahara |
| author_facet | Kaei Nasu Hisashi Narahara |
| author_sort | Kaei Nasu |
| collection | DOAJ |
| description | The mucosal surface of the female genital tract is a complex biosystem, which provides a barrier against the outside world and participates in both innate and acquired immune defense systems. This mucosal compartment has adapted to a dynamic, non-sterile environment challenged by a variety of antigenic/inflammatory stimuli associated with sexual intercourse and endogenous vaginal microbiota. Rapid innate immune defenses against microbial infection usually involve the recognition of invading pathogens by specific pattern-recognition receptors recently attributed to the family of Toll-like receptors (TLRs). TLRs recognize conserved pathogen-associated molecular patterns (PAMPs) synthesized by microorganisms including bacteria, fungi, parasites, and viruses as well as endogenous ligands associated with cell damage. Members of the TLR family, which includes 10 human TLRs identified to date, recognize distinct PAMPs produced by various bacterial, fungal, and viral pathogens. The available literature regarding the innate immune system of the female genital tract during human reproductive processes was reviewed in order to identify studies specifically related to the expression and function of TLRs under normal as well as pathological conditions. Increased understanding of these molecules may provide insight into site-specific immunoregulatory mechanisms in the female reproductive tract. |
| format | Article |
| id | doaj-art-772fb6e98efd4af396e66d00525f8342 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-772fb6e98efd4af396e66d00525f83422025-02-03T06:00:10ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/976024976024Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital TractKaei Nasu0Hisashi Narahara1Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, JapanThe mucosal surface of the female genital tract is a complex biosystem, which provides a barrier against the outside world and participates in both innate and acquired immune defense systems. This mucosal compartment has adapted to a dynamic, non-sterile environment challenged by a variety of antigenic/inflammatory stimuli associated with sexual intercourse and endogenous vaginal microbiota. Rapid innate immune defenses against microbial infection usually involve the recognition of invading pathogens by specific pattern-recognition receptors recently attributed to the family of Toll-like receptors (TLRs). TLRs recognize conserved pathogen-associated molecular patterns (PAMPs) synthesized by microorganisms including bacteria, fungi, parasites, and viruses as well as endogenous ligands associated with cell damage. Members of the TLR family, which includes 10 human TLRs identified to date, recognize distinct PAMPs produced by various bacterial, fungal, and viral pathogens. The available literature regarding the innate immune system of the female genital tract during human reproductive processes was reviewed in order to identify studies specifically related to the expression and function of TLRs under normal as well as pathological conditions. Increased understanding of these molecules may provide insight into site-specific immunoregulatory mechanisms in the female reproductive tract.http://dx.doi.org/10.1155/2010/976024 |
| spellingShingle | Kaei Nasu Hisashi Narahara Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract Mediators of Inflammation |
| title | Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract |
| title_full | Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract |
| title_fullStr | Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract |
| title_full_unstemmed | Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract |
| title_short | Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract |
| title_sort | pattern recognition via the toll like receptor system in the human female genital tract |
| url | http://dx.doi.org/10.1155/2010/976024 |
| work_keys_str_mv | AT kaeinasu patternrecognitionviathetolllikereceptorsysteminthehumanfemalegenitaltract AT hisashinarahara patternrecognitionviathetolllikereceptorsysteminthehumanfemalegenitaltract |