Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts

Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts

Abstract Clinically, phosphodiesterase type 5 inhibitors (PDE5-Is) remain the first-line therapy for erectile dysfunction (ED) patients; however, approximately 35% of these patients are still failing to respond to the therapeutic effects. So, urgent needs are required to identify novel therapeutic t...

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Bibliographic Details
Main Authors: Yi Wang, Guihua Chen, Deng Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Biology Direct
Subjects:
Mendelian randomization
OAS1
Single-cell RNA-sequencing
Erectile dysfunction
Fibroblasts
Online Access:https://doi.org/10.1186/s13062-024-00587-7
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https://doi.org/10.1186/s13062-024-00587-7

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