Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus
Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor- (NF-) κB family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transc...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6927429 |
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| author | Lusha Cen Fengling Xing Liying Xu Yi Cao |
| author_facet | Lusha Cen Fengling Xing Liying Xu Yi Cao |
| author_sort | Lusha Cen |
| collection | DOAJ |
| description | Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor- (NF-) κB family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transcriptional activity in vivo and in vitro. Increased expression of NFAT5 is closely correlated with the progression of diabetes in patients. The distinct structure of NFAT5 governs its physiological and pathogenic roles, indicating its opposing functions. The ability of NFAT5 to maintain cell homeostasis and proliferation is impaired in patients with diabetes. NFAT5 promotes the formation of aldose reductase, pathogenesis of diabetic vascular complications, and insulin resistance. Additionally, NFAT5 activates inflammation at a very early stage of diabetes and induces persistent inflammation. Recent studies revealed that NFAT5 is an effective therapeutic target for diabetes. Here, we describe the current knowledge about NFAT5 and its relationship with diabetes, focusing on its diverse regulatory functions, and highlight the importance of this protein as a potential therapeutic target in patients with diabetes. |
| format | Article |
| id | doaj-art-76ed2e1da61b4cb4a1eded9dadae2ea5 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-76ed2e1da61b4cb4a1eded9dadae2ea52025-02-03T01:05:04ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/69274296927429Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes MellitusLusha Cen0Fengling Xing1Liying Xu2Yi Cao3Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Dermatology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Youdian Rd. 54th, Hangzhou 310006, ChinaNuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor- (NF-) κB family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transcriptional activity in vivo and in vitro. Increased expression of NFAT5 is closely correlated with the progression of diabetes in patients. The distinct structure of NFAT5 governs its physiological and pathogenic roles, indicating its opposing functions. The ability of NFAT5 to maintain cell homeostasis and proliferation is impaired in patients with diabetes. NFAT5 promotes the formation of aldose reductase, pathogenesis of diabetic vascular complications, and insulin resistance. Additionally, NFAT5 activates inflammation at a very early stage of diabetes and induces persistent inflammation. Recent studies revealed that NFAT5 is an effective therapeutic target for diabetes. Here, we describe the current knowledge about NFAT5 and its relationship with diabetes, focusing on its diverse regulatory functions, and highlight the importance of this protein as a potential therapeutic target in patients with diabetes.http://dx.doi.org/10.1155/2020/6927429 |
| spellingShingle | Lusha Cen Fengling Xing Liying Xu Yi Cao Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus Journal of Diabetes Research |
| title | Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus |
| title_full | Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus |
| title_fullStr | Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus |
| title_full_unstemmed | Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus |
| title_short | Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus |
| title_sort | potential role of gene regulator nfat5 in the pathogenesis of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2020/6927429 |
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