Lovastatin Targets the USP14–Survivin Axis to Suppress Triple-Negative Breast Cancer via Ubiquitin-Mediated Proteasomal Degradation

Lovastatin Targets the USP14–Survivin Axis to Suppress Triple-Negative Breast Cancer via Ubiquitin-Mediated Proteasomal Degradation

Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER2) expression, represents a therapeutic challenge due to its aggressive nature and limited treatment options. Here, we ident...

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Bibliographic Details
Main Authors: Li Zhou, Chanjuan Zheng, Siyu Ding, Zhiyu Wang, Yiyuan Yang, Yian Wang, Guangchun He, Shujun Fu, Xiyun Deng
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
TNBC
Survivin
lovastatin
deubiquitination
USP14
Online Access:https://www.mdpi.com/2073-4409/14/11/816
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