Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility

Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility

Abstract Plasmodium malariae parasites are widely observed across the tropics and sub-tropics. This slow-growing species, known to maintain chronic asymptomatic infections, has been associated with reduced antimalarial susceptibility. We analyse 251 P. malariae genomes from 28 countries, and leverag...

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Main Authors: Amy Ibrahim, Franziska Mohring, Emilia Manko, Donelly A. van Schalkwyk, Jody E. Phelan, Debbie Nolder, Steffen Borrmann, Ayola A. Adegnika, Silvia Maria Di Santi, Mohammad Shafiul Alam, Dinesh Mondal, Francois Nosten, Colin J. Sutherland, Robert W. Moon, Taane G. Clark, Susana Campino
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55102-3
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https://doi.org/10.1038/s41467-024-55102-3

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