Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.

<h4>Background</h4>Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis. We previously demonstrated that apelin is one of the most potent endogenous stimulators of cardiac contractility; however, its underly...

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Bibliographic Details
Main Authors: Ábel Perjés, Réka Skoumal, Olli Tenhunen, Attila Kónyi, Mihály Simon, Iván G Horváth, Risto Kerkelä, Heikki Ruskoaho, István Szokodi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093473&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093473&type=printable

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