Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome

Abstract Cellular protein degradation requires a complex molecular machine, the proteasome. To mitigate the fundamental challenge of assembling the 66-subunit proteasome, cells utilize dedicated chaperones to order subunit addition. However, recent evidence suggests that proteasome assembly is not s...

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Bibliographic Details
Main Authors: Eshita Das, Linh Le, Vladyslava Sokolova, James D. Orth, Soyeon Park
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58703-8
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