Ester derivatives of Dictyostelium differentiation-inducing factors exhibit antibacterial activity, possibly via a prodrug-like function

Ester derivatives of Dictyostelium differentiation-inducing factors exhibit antibacterial activity, possibly via a prodrug-like function

Abstract Objective Dictyostelium differentiation-inducing factors 1 and 3 [DIF-1 (1) and DIF-3 (2), respectively], along with their derivatives, such as Ph-DIF-1 (3) and Bu-DIF-3 (4), demonstrate antibacterial activity in vitro against Gram-positive bacteria, including methicillin-sensitive Staphylo...

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Main Authors: Katsunori Takahashi, Haruhisa Kikuchi, Takehiro Nishimura, Hirotaka Ishigaki, Yusuke Miura, Ayuko Takahashi, Yuzuru Kubohara
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Research Notes
Subjects:
Dictyostelium discoideum
Antibacterial agent
Methicillin-resistant Staphylococcus aureus
Vancomycin-resistant Enterococcus faecium
Online Access:https://doi.org/10.1186/s13104-025-07122-5
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https://doi.org/10.1186/s13104-025-07122-5

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