OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression

OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression

Summary: Ferroptosis, a regulated cell demise predicated on iron metabolism and lipid peroxidation, has increasingly become a focal point in oncological therapies. Nonetheless, its governance, particularly the role of deubiquitination, is not fully delineated. This investigation concentrates on the...

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Bibliographic Details
Main Authors: Jinglian Chen, Chengqing Huang, Jiale Mei, Qiuhua Lin, Wenbo Chen, Jiali Tang, Xinjie Wei, Caixia Mo, Yueyan Zhang, Qi Zeng, Xianwei Mo, Weizhong Tang, Tao Luo
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004528
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