Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial

Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial

Background: Intraoperative awareness, without explicit recall, occurs after induction of anaesthesia in approximately 10% of persons under 40 yr of age. Most anaesthetic agents minimally suppress the noradrenergic system. We hypothesised that addition of dexmedetomidine, which suppresses noradrenerg...

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Bibliographic Details
Main Authors: Kaitlin Kramer, Thomas Payne, Mitchell Brooks, Jessica Barry, Neha Mahajan, Samantha Malcolm, Hannah Braithwaite, Alex Wang, Chris Thompson, Keith Liyanagama, Robert D. Sanders
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:BJA Open
Subjects:
accidental awareness under general anaesthesia
anaesthesia
connected consciousness
dexmedetomidine
surgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609624001096
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