Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment

Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment

The hypoxia-inducible factor-1α (HIF-1α) plays a key role in facilitating the adaptation of cells to hypoxia, profoundly influencing the immune vascular microenvironment (IVM) and immunotherapy outcomes. HIF-1α-mediated tumor hypoxia drives angiogenesis, immune suppression, and extracellular matrix...

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Bibliographic Details
Main Authors: Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
HIF-1 α
VEGF
immune vascular microenvironment
immunotherapy resistance
personalized cancer therapy
machine learning HIF-1a
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1549276/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1549276/full

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