Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes

Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes

Abstract Background/Purpose Knowledge of the 3D genome is essential to elucidate genetic mechanisms driving autoimmune diseases. The 3D genome is distinct for each cell type, and it is uncertain whether cell lines faithfully recapitulate the 3D architecture of primary human cells or whether developm...

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Bibliographic Details
Main Authors: Kaiyu Jiang, Yao Fu, Jennifer A. Kelly, Patrick M. Gaffney, Lucy C. Holmes, James N. Jarvis
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medical Genomics
Subjects:
B cells
Chromatin accessibility
Chromatin conformation
Pediatric autoimmune disease
Juvenile arthritis
Systemic lupus
Online Access:https://doi.org/10.1186/s12920-025-02166-9
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https://doi.org/10.1186/s12920-025-02166-9

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